diff --git a/var/spack/repos/builtin/packages/libfabric/package.py b/var/spack/repos/builtin/packages/libfabric/package.py
index 85e27e658f4..d836a24fe57 100644
--- a/var/spack/repos/builtin/packages/libfabric/package.py
+++ b/var/spack/repos/builtin/packages/libfabric/package.py
@@ -131,6 +131,7 @@ class Libfabric(AutotoolsPackage, CudaPackage):
     depends_on("liburing@2.1:", when="+uring")
     depends_on("oneapi-level-zero", when="+level_zero")
     depends_on("libcxi", when="fabrics=cxi")
+    depends_on("xpmem", when="fabrics=xpmem")
 
     depends_on("m4", when="@main", type="build")
     depends_on("autoconf", when="@main", type="build")
@@ -215,6 +216,9 @@ def configure_args(self):
             args.append(f"--with-cxi-uapi-headers={self.spec['cxi-driver'].prefix.include}")
             args.append(f"--enable-cxi={self.spec['libcxi'].prefix}")
 
+        if self.spec.satisfies("fabrics=xpmem"):
+            args.append(f"--enable-xpmem={self.spec['xpmem'].prefix}")
+
         return args
 
     def installcheck(self):