diff --git a/lib/spack/spack/build_environment.py b/lib/spack/spack/build_environment.py
index 3f6830ad334..76080185415 100644
--- a/lib/spack/spack/build_environment.py
+++ b/lib/spack/spack/build_environment.py
@@ -1016,10 +1016,17 @@ def get_env_modifications(self) -> EnvironmentModifications:
                 self._make_runnable(dspec, env)
 
             if self.should_setup_run_env & flag:
+                run_env_mods = EnvironmentModifications()
                 for spec in dspec.dependents(deptype=dt.LINK | dt.RUN):
                     if id(spec) in self.nodes_in_subdag:
-                        pkg.setup_dependent_run_environment(env, spec)
-                pkg.setup_run_environment(env)
+                        pkg.setup_dependent_run_environment(run_env_mods, spec)
+                pkg.setup_run_environment(run_env_mods)
+                run_env_dict = run_env_mods.group_by_name()
+                if self.context == Context.BUILD:
+                    run_env_mods.drop("CC", "CXX", "F77", "FC")
+                env.extend(run_env_mods)
+
+
         return env
 
     def _make_buildtime_detectable(self, dep: spack.spec.Spec, env: EnvironmentModifications):
diff --git a/lib/spack/spack/util/environment.py b/lib/spack/spack/util/environment.py
index 246df65cb88..d4c352b9935 100644
--- a/lib/spack/spack/util/environment.py
+++ b/lib/spack/spack/util/environment.py
@@ -596,6 +596,14 @@ def group_by_name(self) -> Dict[str, ModificationList]:
             modifications[item.name].append(item)
         return modifications
 
+    def drop(self, *name) -> bool:
+        """Drop all modifications to the variable with the given name."""
+        old_mods = self.env_modifications
+        new_mods = [x for x in self.env_modifications if x.name not in name]
+        self.env_modifications = new_mods
+
+        return len(old_mods) != len(new_mods)
+
     def is_unset(self, variable_name: str) -> bool:
         """Returns True if the last modification to a variable is to unset it, False otherwise."""
         modifications = self.group_by_name()