diff --git a/var/spack/repos/builtin/packages/py-hmmlearn/package.py b/var/spack/repos/builtin/packages/py-hmmlearn/package.py
index 0a47bf3138d..3f4848f1a53 100644
--- a/var/spack/repos/builtin/packages/py-hmmlearn/package.py
+++ b/var/spack/repos/builtin/packages/py-hmmlearn/package.py
@@ -16,12 +16,15 @@ class PyHmmlearn(PythonPackage):
 
     license("BSD-3-Clause")
 
+    version("0.3.3", sha256="1d3c5dc4c5257e0c238dc1fe5387700b8cb987eab808edb3e0c73829f1cc44ec")
     version("0.3.0", sha256="d13a91ea3695df881465e3d36132d7eef4e84d483f4ba538a4b46e24b5ea100f")
 
     depends_on("cxx", type="build")  # generated
 
-    depends_on("py-setuptools", type="build")
-    depends_on("py-setuptools-scm@3.3:", type="build")
+    depends_on("py-setuptools@62:", when="@0.3.3:", type="build")
+    depends_on("py-setuptools", when="@:0.3.2", type="build")
+    depends_on("py-setuptools-scm@6.2:", when="@0.3.3:", type="build")
+    depends_on("py-setuptools-scm@3.3:", when="@:0.3.2", type="build")
     depends_on("py-pybind11@2.6:", type="build")
 
     depends_on("py-numpy@1.10:", type=("build", "run"))
diff --git a/var/spack/repos/builtin/packages/py-macs3/package.py b/var/spack/repos/builtin/packages/py-macs3/package.py
index f8fe4c721d1..8644e4a5ac5 100644
--- a/var/spack/repos/builtin/packages/py-macs3/package.py
+++ b/var/spack/repos/builtin/packages/py-macs3/package.py
@@ -9,23 +9,37 @@ class PyMacs3(PythonPackage):
     """MACS: Model-based Analysis for ChIP-Seq"""
 
     homepage = "https://github.com/macs3-project/MACS/"
-    pypi = "MACS3/MACS3-3.0.0b3.tar.gz"
+    pypi = "MACS3/macs3-3.0.2.tar.gz"
 
     maintainers("snehring")
 
     license("BSD-3-Clause")
 
+    version("3.0.3", sha256="ee1c892901c4010ff9e201b433c0623cbd747a3058300322386a7185623b1684")
     version("3.0.0b3", sha256="caa794d4cfcd7368447eae15878505315dac44c21546e8fecebb3561e9cee362")
 
-    depends_on("c", type="build")  # generated
+    def url_for_version(self, version):
+        if version < Version("3.0.2"):
+            url_fmt = "https://files.pythonhosted.org/packages/b1/88/df5436ec1510d635e7c41f2aee185da35d6d98ccde9bf1ec5a67ad2bbd62/MACS3-{}.tar.gz"
+            return url_fmt.format(version)
+        return super().url_for_version(version)
 
     depends_on("python@3.9:", type=("build", "run"))
+    depends_on("py-setuptools@68.0:", when="@3.0.2:", type="build")
+    depends_on("py-setuptools@60.0:", when="@:3.0.1", type="build")
+    depends_on("py-cython@3.0", when="@3.0.2:", type=("build", "run"))
+    depends_on("py-cython@0.29:0", when="@:3.0.1", type=("build", "run"))
 
-    depends_on("py-setuptools@60.0:", type="build")
-    depends_on("py-cython@0.29:0", type=("build", "run"))
-
-    depends_on("py-numpy@1.19:", type=("build", "run"))
+    depends_on("py-numpy@1.25:", when="@3.0.3:", type=("build", "run"))
+    depends_on("py-numpy@1.24.2:", when="@3.0.1:3.0.2", type=("build", "run"))
+    depends_on("py-numpy@1.19:", when="@:3.0.0", type=("build", "run"))
+    depends_on("py-scipy@1.12:", when="@3.0.3:", type=("build", "run"))
+    depends_on("py-scipy@1.11.4:", when="@3.0.1:3.0.2", type=("build", "run"))
     depends_on("py-cykhash@2", type=("build", "run"))
-    depends_on("py-hmmlearn@0.3:", type=("build", "run"))
+    depends_on("py-scikit-learn@1.3:", when="@3.0.2:", type=("build", "run"))
+    depends_on("py-scikit-learn@1.2.1:", when="@3.0.1", type=("build", "run"))
+    depends_on("py-hmmlearn@0.3.2:", when="@3.0.2:", type=("build", "run"))
+    depends_on("py-hmmlearn@0.3:", when="@:3.0.1", type=("build", "run"))
 
     depends_on("zlib-api")
+    depends_on("c", type="build")  # generated