diff --git a/lib/spack/spack/cmd/buildcache.py b/lib/spack/spack/cmd/buildcache.py
index a76cfa767f6..80a579a3b71 100644
--- a/lib/spack/spack/cmd/buildcache.py
+++ b/lib/spack/spack/cmd/buildcache.py
@@ -76,9 +76,6 @@ def setup_parser(subparser: argparse.ArgumentParser):
         default=False,
         help="regenerate buildcache index after building package(s)",
     )
-    push.add_argument(
-        "--spec-file", default=None, help="create buildcache entry for spec from json or yaml file"
-    )
     push.add_argument(
         "--only",
         default="package,dependencies",
@@ -192,28 +189,14 @@ def setup_parser(subparser: argparse.ArgumentParser):
         default=lambda: spack.config.default_modify_scope(),
         help="configuration scope containing mirrors to check",
     )
-    # Unfortunately there are 3 ways to do the same thing here:
-    check_specs = check.add_mutually_exclusive_group()
-    check_specs.add_argument(
-        "-s", "--spec", help="check single spec instead of release specs file"
-    )
-    check_specs.add_argument(
-        "--spec-file",
-        help="check single spec from json or yaml file instead of release specs file",
-    )
+
     arguments.add_common_arguments(check, ["specs"])
 
     check.set_defaults(func=check_fn)
 
     # Download tarball and specfile
     download = subparsers.add_parser("download", help=download_fn.__doc__)
-    download_spec_or_specfile = download.add_mutually_exclusive_group(required=True)
-    download_spec_or_specfile.add_argument(
-        "-s", "--spec", help="download built tarball for spec from mirror"
-    )
-    download_spec_or_specfile.add_argument(
-        "--spec-file", help="download built tarball for spec (from json or yaml file) from mirror"
-    )
+    download.add_argument("-s", "--spec", help="download built tarball for spec from mirror")
     download.add_argument(
         "-p",
         "--path",
@@ -223,28 +206,10 @@ def setup_parser(subparser: argparse.ArgumentParser):
     )
     download.set_defaults(func=download_fn)
 
-    # Get buildcache name
-    getbuildcachename = subparsers.add_parser(
-        "get-buildcache-name", help=get_buildcache_name_fn.__doc__
-    )
-    getbuildcachename_spec_or_specfile = getbuildcachename.add_mutually_exclusive_group(
-        required=True
-    )
-    getbuildcachename_spec_or_specfile.add_argument(
-        "-s", "--spec", help="spec string for which buildcache name is desired"
-    )
-    getbuildcachename_spec_or_specfile.add_argument(
-        "--spec-file", help="path to spec json or yaml file for which buildcache name is desired"
-    )
-    getbuildcachename.set_defaults(func=get_buildcache_name_fn)
-
     # Given the root spec, save the yaml of the dependent spec to a file
     savespecfile = subparsers.add_parser("save-specfile", help=save_specfile_fn.__doc__)
     savespecfile_spec_or_specfile = savespecfile.add_mutually_exclusive_group(required=True)
     savespecfile_spec_or_specfile.add_argument("--root-spec", help="root spec of dependent spec")
-    savespecfile_spec_or_specfile.add_argument(
-        "--root-specfile", help="path to json or yaml file containing root spec of dependent spec"
-    )
     savespecfile.add_argument(
         "-s",
         "--specs",
@@ -380,14 +345,8 @@ def _specs_to_be_packaged(
 
 def push_fn(args):
     """create a binary package and push it to a mirror"""
-    if args.spec_file:
-        tty.warn(
-            "The flag `--spec-file` is deprecated and will be removed in Spack 0.22. "
-            "Use positional arguments instead."
-        )
-
-    if args.specs or args.spec_file:
-        roots = _matching_specs(spack.cmd.parse_specs(args.specs or args.spec_file))
+    if args.specs:
+        roots = _matching_specs(spack.cmd.parse_specs(args.specs))
     else:
         roots = spack.cmd.require_active_env(cmd_name="buildcache push").concrete_roots()
 
@@ -529,22 +488,7 @@ def check_fn(args: argparse.Namespace):
     this command uses the process exit code to indicate its result, specifically, if the
     exit code is non-zero, then at least one of the indicated specs needs to be rebuilt
     """
-    if args.spec_file:
-        specs_arg = (
-            args.spec_file if os.path.sep in args.spec_file else os.path.join(".", args.spec_file)
-        )
-        tty.warn(
-            "The flag `--spec-file` is deprecated and will be removed in Spack 0.22. "
-            f"Use `spack buildcache check {specs_arg}` instead."
-        )
-    elif args.spec:
-        specs_arg = args.spec
-        tty.warn(
-            "The flag `--spec` is deprecated and will be removed in Spack 0.23. "
-            f"Use `spack buildcache check {specs_arg}` instead."
-        )
-    else:
-        specs_arg = args.specs
+    specs_arg = args.specs
 
     if specs_arg:
         specs = _matching_specs(spack.cmd.parse_specs(specs_arg))
@@ -578,13 +522,7 @@ def download_fn(args):
     code indicates that the command failed to download at least one of the required buildcache
     components
     """
-    if args.spec_file:
-        tty.warn(
-            "The flag `--spec-file` is deprecated and will be removed in Spack 0.22. "
-            "Use --spec instead."
-        )
-
-    specs = _matching_specs(spack.cmd.parse_specs(args.spec or args.spec_file))
+    specs = _matching_specs(spack.cmd.parse_specs(args.spec))
 
     if len(specs) != 1:
         tty.die("a single spec argument is required to download from a buildcache")
@@ -593,15 +531,6 @@ def download_fn(args):
         sys.exit(1)
 
 
-def get_buildcache_name_fn(args):
-    """get name (prefix) of buildcache entries for this spec"""
-    tty.warn("This command is deprecated and will be removed in Spack 0.22.")
-    specs = _matching_specs(spack.cmd.parse_specs(args.spec or args.spec_file))
-    if len(specs) != 1:
-        tty.die("a single spec argument is required to get buildcache name")
-    print(bindist.tarball_name(specs[0], ""))
-
-
 def save_specfile_fn(args):
     """get full spec for dependencies and write them to files in the specified output directory
 
@@ -609,13 +538,7 @@ def save_specfile_fn(args):
     successful. if any errors or exceptions are encountered, or if expected command-line arguments
     are not provided, then the exit code will be non-zero
     """
-    if args.root_specfile:
-        tty.warn(
-            "The flag `--root-specfile` is deprecated and will be removed in Spack 0.22. "
-            "Use --root-spec instead."
-        )
-
-    specs = spack.cmd.parse_specs(args.root_spec or args.root_specfile)
+    specs = spack.cmd.parse_specs(args.root_spec)
 
     if len(specs) != 1:
         tty.die("a single spec argument is required to save specfile")
diff --git a/lib/spack/spack/test/cmd/ci.py b/lib/spack/spack/test/cmd/ci.py
index b1201efbe74..da1ce50c77e 100644
--- a/lib/spack/spack/test/cmd/ci.py
+++ b/lib/spack/spack/test/cmd/ci.py
@@ -873,10 +873,6 @@ def test_push_to_build_cache(
             ci.copy_stage_logs_to_artifacts(concrete_spec, str(logs_dir))
             assert "spack-build-out.txt.gz" in os.listdir(logs_dir)
 
-            dl_dir = scratch / "download_dir"
-            buildcache_cmd("download", "--spec-file", json_path, "--path", str(dl_dir))
-            assert len(os.listdir(dl_dir)) == 2
-
 
 def test_push_to_build_cache_exceptions(monkeypatch, tmp_path, capsys):
     def push_or_raise(*args, **kwargs):
diff --git a/share/spack/spack-completion.bash b/share/spack/spack-completion.bash
index 65d276b9743..7abaf6ff785 100644
--- a/share/spack/spack-completion.bash
+++ b/share/spack/spack-completion.bash
@@ -563,14 +563,14 @@ _spack_buildcache() {
     then
         SPACK_COMPREPLY="-h --help"
     else
-        SPACK_COMPREPLY="push create install list keys check download get-buildcache-name save-specfile sync update-index rebuild-index"
+        SPACK_COMPREPLY="push create install list keys check download save-specfile sync update-index rebuild-index"
     fi
 }
 
 _spack_buildcache_push() {
     if $list_options
     then
-        SPACK_COMPREPLY="-h --help -f --force --unsigned -u --signed --key -k --update-index --rebuild-index --spec-file --only --with-build-dependencies --without-build-dependencies --fail-fast --base-image --tag -t --private -j --jobs"
+        SPACK_COMPREPLY="-h --help -f --force --unsigned -u --signed --key -k --update-index --rebuild-index --only --with-build-dependencies --without-build-dependencies --fail-fast --base-image --tag -t --private -j --jobs"
     else
         _mirrors
     fi
@@ -579,7 +579,7 @@ _spack_buildcache_push() {
 _spack_buildcache_create() {
     if $list_options
     then
-        SPACK_COMPREPLY="-h --help -f --force --unsigned -u --signed --key -k --update-index --rebuild-index --spec-file --only --with-build-dependencies --without-build-dependencies --fail-fast --base-image --tag -t --private -j --jobs"
+        SPACK_COMPREPLY="-h --help -f --force --unsigned -u --signed --key -k --update-index --rebuild-index --only --with-build-dependencies --without-build-dependencies --fail-fast --base-image --tag -t --private -j --jobs"
     else
         _mirrors
     fi
@@ -610,22 +610,18 @@ _spack_buildcache_keys() {
 _spack_buildcache_check() {
     if $list_options
     then
-        SPACK_COMPREPLY="-h --help -m --mirror-url -o --output-file --scope -s --spec --spec-file"
+        SPACK_COMPREPLY="-h --help -m --mirror-url -o --output-file --scope"
     else
         _all_packages
     fi
 }
 
 _spack_buildcache_download() {
-    SPACK_COMPREPLY="-h --help -s --spec --spec-file -p --path"
-}
-
-_spack_buildcache_get_buildcache_name() {
-    SPACK_COMPREPLY="-h --help -s --spec --spec-file"
+    SPACK_COMPREPLY="-h --help -s --spec -p --path"
 }
 
 _spack_buildcache_save_specfile() {
-    SPACK_COMPREPLY="-h --help --root-spec --root-specfile -s --specs --specfile-dir"
+    SPACK_COMPREPLY="-h --help --root-spec -s --specs --specfile-dir"
 }
 
 _spack_buildcache_sync() {
diff --git a/share/spack/spack-completion.fish b/share/spack/spack-completion.fish
index 0a6c986757f..9d53ea526ec 100644
--- a/share/spack/spack-completion.fish
+++ b/share/spack/spack-completion.fish
@@ -693,7 +693,6 @@ complete -c spack -n '__fish_spack_using_command_pos 0 buildcache' -f -a list -d
 complete -c spack -n '__fish_spack_using_command_pos 0 buildcache' -f -a keys -d 'get public keys available on mirrors'
 complete -c spack -n '__fish_spack_using_command_pos 0 buildcache' -f -a check -d 'check specs against remote binary mirror(s) to see if any need to be rebuilt'
 complete -c spack -n '__fish_spack_using_command_pos 0 buildcache' -f -a download -d 'download buildcache entry from a remote mirror to local folder'
-complete -c spack -n '__fish_spack_using_command_pos 0 buildcache' -f -a get-buildcache-name -d 'get name (prefix) of buildcache entries for this spec'
 complete -c spack -n '__fish_spack_using_command_pos 0 buildcache' -f -a save-specfile -d 'get full spec for dependencies and write them to files in the specified output directory'
 complete -c spack -n '__fish_spack_using_command_pos 0 buildcache' -f -a sync -d 'sync binaries (and associated metadata) from one mirror to another'
 complete -c spack -n '__fish_spack_using_command_pos 0 buildcache' -f -a update-index -d 'update a buildcache index'
@@ -702,7 +701,7 @@ complete -c spack -n '__fish_spack_using_command buildcache' -s h -l help -f -a
 complete -c spack -n '__fish_spack_using_command buildcache' -s h -l help -d 'show this help message and exit'
 
 # spack buildcache push
-set -g __fish_spack_optspecs_spack_buildcache_push h/help f/force u/unsigned signed k/key= update-index spec-file= only= with-build-dependencies without-build-dependencies fail-fast base-image= t/tag= private j/jobs=
+set -g __fish_spack_optspecs_spack_buildcache_push h/help f/force u/unsigned signed k/key= update-index only= with-build-dependencies without-build-dependencies fail-fast base-image= t/tag= private j/jobs=
 complete -c spack -n '__fish_spack_using_command_pos_remainder 1 buildcache push' -f -k -a '(__fish_spack_specs)'
 complete -c spack -n '__fish_spack_using_command buildcache push' -s h -l help -f -a help
 complete -c spack -n '__fish_spack_using_command buildcache push' -s h -l help -d 'show this help message and exit'
@@ -716,8 +715,6 @@ complete -c spack -n '__fish_spack_using_command buildcache push' -l key -s k -r
 complete -c spack -n '__fish_spack_using_command buildcache push' -l key -s k -r -d 'key for signing'
 complete -c spack -n '__fish_spack_using_command buildcache push' -l update-index -l rebuild-index -f -a update_index
 complete -c spack -n '__fish_spack_using_command buildcache push' -l update-index -l rebuild-index -d 'regenerate buildcache index after building package(s)'
-complete -c spack -n '__fish_spack_using_command buildcache push' -l spec-file -r -f -a spec_file
-complete -c spack -n '__fish_spack_using_command buildcache push' -l spec-file -r -d 'create buildcache entry for spec from json or yaml file'
 complete -c spack -n '__fish_spack_using_command buildcache push' -l only -r -f -a 'package dependencies'
 complete -c spack -n '__fish_spack_using_command buildcache push' -l only -r -d 'select the buildcache mode. The default is to build a cache for the package along with all its dependencies. Alternatively, one can decide to build a cache for only the package or only the dependencies'
 complete -c spack -n '__fish_spack_using_command buildcache push' -l with-build-dependencies -f -a with_build_dependencies
@@ -736,7 +733,7 @@ complete -c spack -n '__fish_spack_using_command buildcache push' -s j -l jobs -
 complete -c spack -n '__fish_spack_using_command buildcache push' -s j -l jobs -r -d 'explicitly set number of parallel jobs'
 
 # spack buildcache create
-set -g __fish_spack_optspecs_spack_buildcache_create h/help f/force u/unsigned signed k/key= update-index spec-file= only= with-build-dependencies without-build-dependencies fail-fast base-image= t/tag= private j/jobs=
+set -g __fish_spack_optspecs_spack_buildcache_create h/help f/force u/unsigned signed k/key= update-index only= with-build-dependencies without-build-dependencies fail-fast base-image= t/tag= private j/jobs=
 complete -c spack -n '__fish_spack_using_command_pos_remainder 1 buildcache create' -f -k -a '(__fish_spack_specs)'
 complete -c spack -n '__fish_spack_using_command buildcache create' -s h -l help -f -a help
 complete -c spack -n '__fish_spack_using_command buildcache create' -s h -l help -d 'show this help message and exit'
@@ -750,8 +747,6 @@ complete -c spack -n '__fish_spack_using_command buildcache create' -l key -s k
 complete -c spack -n '__fish_spack_using_command buildcache create' -l key -s k -r -d 'key for signing'
 complete -c spack -n '__fish_spack_using_command buildcache create' -l update-index -l rebuild-index -f -a update_index
 complete -c spack -n '__fish_spack_using_command buildcache create' -l update-index -l rebuild-index -d 'regenerate buildcache index after building package(s)'
-complete -c spack -n '__fish_spack_using_command buildcache create' -l spec-file -r -f -a spec_file
-complete -c spack -n '__fish_spack_using_command buildcache create' -l spec-file -r -d 'create buildcache entry for spec from json or yaml file'
 complete -c spack -n '__fish_spack_using_command buildcache create' -l only -r -f -a 'package dependencies'
 complete -c spack -n '__fish_spack_using_command buildcache create' -l only -r -d 'select the buildcache mode. The default is to build a cache for the package along with all its dependencies. Alternatively, one can decide to build a cache for only the package or only the dependencies'
 complete -c spack -n '__fish_spack_using_command buildcache create' -l with-build-dependencies -f -a with_build_dependencies
@@ -811,7 +806,7 @@ complete -c spack -n '__fish_spack_using_command buildcache keys' -s f -l force
 complete -c spack -n '__fish_spack_using_command buildcache keys' -s f -l force -d 'force new download of keys'
 
 # spack buildcache check
-set -g __fish_spack_optspecs_spack_buildcache_check h/help m/mirror-url= o/output-file= scope= s/spec= spec-file=
+set -g __fish_spack_optspecs_spack_buildcache_check h/help m/mirror-url= o/output-file= scope=
 complete -c spack -n '__fish_spack_using_command_pos_remainder 0 buildcache check' -f -k -a '(__fish_spack_specs)'
 complete -c spack -n '__fish_spack_using_command buildcache check' -s h -l help -f -a help
 complete -c spack -n '__fish_spack_using_command buildcache check' -s h -l help -d 'show this help message and exit'
@@ -821,39 +816,22 @@ complete -c spack -n '__fish_spack_using_command buildcache check' -s o -l outpu
 complete -c spack -n '__fish_spack_using_command buildcache check' -s o -l output-file -r -d 'file where rebuild info should be written'
 complete -c spack -n '__fish_spack_using_command buildcache check' -l scope -r -f -a '_builtin defaults system site user command_line'
 complete -c spack -n '__fish_spack_using_command buildcache check' -l scope -r -d 'configuration scope containing mirrors to check'
-complete -c spack -n '__fish_spack_using_command buildcache check' -s s -l spec -r -f -a spec
-complete -c spack -n '__fish_spack_using_command buildcache check' -s s -l spec -r -d 'check single spec instead of release specs file'
-complete -c spack -n '__fish_spack_using_command buildcache check' -l spec-file -r -f -a spec_file
-complete -c spack -n '__fish_spack_using_command buildcache check' -l spec-file -r -d 'check single spec from json or yaml file instead of release specs file'
 
 # spack buildcache download
-set -g __fish_spack_optspecs_spack_buildcache_download h/help s/spec= spec-file= p/path=
+set -g __fish_spack_optspecs_spack_buildcache_download h/help s/spec= p/path=
 complete -c spack -n '__fish_spack_using_command buildcache download' -s h -l help -f -a help
 complete -c spack -n '__fish_spack_using_command buildcache download' -s h -l help -d 'show this help message and exit'
 complete -c spack -n '__fish_spack_using_command buildcache download' -s s -l spec -r -f -a spec
 complete -c spack -n '__fish_spack_using_command buildcache download' -s s -l spec -r -d 'download built tarball for spec from mirror'
-complete -c spack -n '__fish_spack_using_command buildcache download' -l spec-file -r -f -a spec_file
-complete -c spack -n '__fish_spack_using_command buildcache download' -l spec-file -r -d 'download built tarball for spec (from json or yaml file) from mirror'
 complete -c spack -n '__fish_spack_using_command buildcache download' -s p -l path -r -f -a path
 complete -c spack -n '__fish_spack_using_command buildcache download' -s p -l path -r -d 'path to directory where tarball should be downloaded'
 
-# spack buildcache get-buildcache-name
-set -g __fish_spack_optspecs_spack_buildcache_get_buildcache_name h/help s/spec= spec-file=
-complete -c spack -n '__fish_spack_using_command buildcache get-buildcache-name' -s h -l help -f -a help
-complete -c spack -n '__fish_spack_using_command buildcache get-buildcache-name' -s h -l help -d 'show this help message and exit'
-complete -c spack -n '__fish_spack_using_command buildcache get-buildcache-name' -s s -l spec -r -f -a spec
-complete -c spack -n '__fish_spack_using_command buildcache get-buildcache-name' -s s -l spec -r -d 'spec string for which buildcache name is desired'
-complete -c spack -n '__fish_spack_using_command buildcache get-buildcache-name' -l spec-file -r -f -a spec_file
-complete -c spack -n '__fish_spack_using_command buildcache get-buildcache-name' -l spec-file -r -d 'path to spec json or yaml file for which buildcache name is desired'
-
 # spack buildcache save-specfile
-set -g __fish_spack_optspecs_spack_buildcache_save_specfile h/help root-spec= root-specfile= s/specs= specfile-dir=
+set -g __fish_spack_optspecs_spack_buildcache_save_specfile h/help root-spec= s/specs= specfile-dir=
 complete -c spack -n '__fish_spack_using_command buildcache save-specfile' -s h -l help -f -a help
 complete -c spack -n '__fish_spack_using_command buildcache save-specfile' -s h -l help -d 'show this help message and exit'
 complete -c spack -n '__fish_spack_using_command buildcache save-specfile' -l root-spec -r -f -a root_spec
 complete -c spack -n '__fish_spack_using_command buildcache save-specfile' -l root-spec -r -d 'root spec of dependent spec'
-complete -c spack -n '__fish_spack_using_command buildcache save-specfile' -l root-specfile -r -f -a root_specfile
-complete -c spack -n '__fish_spack_using_command buildcache save-specfile' -l root-specfile -r -d 'path to json or yaml file containing root spec of dependent spec'
 complete -c spack -n '__fish_spack_using_command buildcache save-specfile' -s s -l specs -r -f -a specs
 complete -c spack -n '__fish_spack_using_command buildcache save-specfile' -s s -l specs -r -d 'list of dependent specs for which saved yaml is desired'
 complete -c spack -n '__fish_spack_using_command buildcache save-specfile' -l specfile-dir -r -f -a specfile_dir