diff --git a/var/spack/repos/builtin/packages/py-pip/package.py b/var/spack/repos/builtin/packages/py-pip/package.py
index f674ae41e12..58273a7c9a6 100644
--- a/var/spack/repos/builtin/packages/py-pip/package.py
+++ b/var/spack/repos/builtin/packages/py-pip/package.py
@@ -24,6 +24,8 @@ class PyPip(Package, PythonExtension):
 
     license("MIT")
 
+    version("25.0.1", sha256="c46efd13b6aa8279f33f2864459c8ce587ea6a1a59ee20de055868d8f7688f7f")
+    version("25.0", sha256="b6eb97a803356a52b2dd4bb73ba9e65b2ba16caa6bcb25a7497350a4e5859b65")
     version("24.3.1", sha256="3790624780082365f47549d032f3770eeb2b1e8bd1f7b2e02dace1afa361b4ed")
     version("24.2", sha256="2cd581cf58ab7fcfca4ce8efa6dcacd0de5bf8d0a3eb9ec927e07405f4d9e2a2")
     version("24.1.2", sha256="7cd207eed4c60b0f411b444cd1464198fe186671c323b6cd6d433ed80fc9d247")
diff --git a/var/spack/repos/builtin/packages/py-setuptools/package.py b/var/spack/repos/builtin/packages/py-setuptools/package.py
index 3a7355d1013..54b88684199 100644
--- a/var/spack/repos/builtin/packages/py-setuptools/package.py
+++ b/var/spack/repos/builtin/packages/py-setuptools/package.py
@@ -118,6 +118,14 @@ class PySetuptools(Package, PythonExtension):
 
     depends_on("py-pip", type="build")
 
+    conflicts(
+        "^python@:3.9 ^py-pip@25:",
+        when="@:75.1.0",
+        msg="py-pip@25: vendors pyproject-hooks@1.2. "
+        "The combination pyproject-hooks@1.2, python@:3.9, and py-setuptools@:75.1.0 is broken. "
+        "See https://github.com/pypa/pyproject-hooks/issues/206 for details.",
+    )
+
     def url_for_version(self, version):
         url = "https://files.pythonhosted.org/packages/{0}/s/setuptools/setuptools-{1}-{0}-none-any.whl"