diff --git a/var/spack/repos/builtin/packages/glib/package.py b/var/spack/repos/builtin/packages/glib/package.py
index b7cf326e858..9e71ccdd4bb 100644
--- a/var/spack/repos/builtin/packages/glib/package.py
+++ b/var/spack/repos/builtin/packages/glib/package.py
@@ -159,6 +159,11 @@ def configure_args(self):
         args.append('GTKDOC_REBASE={0}'.format(true))
         return args
 
+    def setup_build_environment(self, env):
+        if self.spec.satisfies('platform=darwin'):
+            # https://github.com/pybind/pybind11/issues/595
+            env.set('STRIP', 'strip -x')
+
     @when('@:2.57.99')
     def install(self, spec, prefix):
         configure('--prefix={0}'.format(prefix), *self.configure_args())