diff --git a/var/spack/repos/builtin/packages/cuda/package.py b/var/spack/repos/builtin/packages/cuda/package.py
index df71f626086..13675fb7744 100644
--- a/var/spack/repos/builtin/packages/cuda/package.py
+++ b/var/spack/repos/builtin/packages/cuda/package.py
@@ -73,6 +73,14 @@ class Cuda(Package):
     # Mojave support -- only macOS High Sierra 10.13 is supported.
     conflicts('arch=darwin-mojave-x86_64')
 
+    depends_on('libxml2', when='@10.1.243:')
+
+    def setup_build_environment(self, env):
+        if self.spec.satisfies('@10.1.243:'):
+            libxml2_home  = self.spec['libxml2'].prefix
+            env.set('LIBXML2HOME', libxml2_home)
+            env.append_path('LD_LIBRARY_PATH', libxml2_home.lib)
+
     def setup_run_environment(self, env):
         env.set('CUDA_HOME', self.prefix)