diff --git a/var/spack/repos/builtin/packages/warpx/package.py b/var/spack/repos/builtin/packages/warpx/package.py
index 1b9cc4b727a..07068f950a5 100644
--- a/var/spack/repos/builtin/packages/warpx/package.py
+++ b/var/spack/repos/builtin/packages/warpx/package.py
@@ -225,6 +225,10 @@ def cmake_args(self):
         if "+sensei" in spec:
             args.append(self.define("SENSEI_DIR", spec["sensei"].prefix.lib.cmake))
 
+        # WarpX uses CCache by default, interfering with Spack wrappers
+        ccache_var = "CCACHE_PROGRAM" if spec.satisfies("@:24.01") else "WarpX_CCACHE"
+        args.append(self.define(ccache_var, False))
+
         return args
 
     @property