diff --git a/var/spack/repos/builtin/packages/libfabric/package.py b/var/spack/repos/builtin/packages/libfabric/package.py
index 0c296736fb8..db73e246df9 100644
--- a/var/spack/repos/builtin/packages/libfabric/package.py
+++ b/var/spack/repos/builtin/packages/libfabric/package.py
@@ -157,11 +157,13 @@ def setup_build_environment(self, env):
     def setup_run_environment(self, env):
         libfabric_home = self.spec["libfabric"].prefix
         env.prepend_path("LD_LIBRARY_PATH", libfabric_home.lib)
+        env.prepend_path("LD_LIBRARY_PATH", libfabric_home.lib64)
 
     # To enable this package add it to the LD_LIBRARY_PATH
     def setup_dependent_run_environment(self, env, dependent_spec):
         libfabric_home = self.spec["libfabric"].prefix
         env.prepend_path("LD_LIBRARY_PATH", libfabric_home.lib)
+        env.prepend_path("LD_LIBRARY_PATH", libfabric_home.lib64)
 
     @when("@main")
     def autoreconf(self, spec, prefix):
diff --git a/var/spack/repos/builtin/packages/llvm-amdgpu/package.py b/var/spack/repos/builtin/packages/llvm-amdgpu/package.py
index 459d2fb40ff..fef8e1f7085 100644
--- a/var/spack/repos/builtin/packages/llvm-amdgpu/package.py
+++ b/var/spack/repos/builtin/packages/llvm-amdgpu/package.py
@@ -307,3 +307,13 @@ def determine_version(cls, path):
                     int(match.group(1)), int(match.group(2)), int(match.group(3))
                 )
         return detected_version
+
+    # Make sure that the compiler paths are in the LD_LIBRARY_PATH
+    def setup_run_environment(self, env):
+        llvm_amdgpu_home = self.spec["llvm-amdgpu"].prefix
+        env.prepend_path("LD_LIBRARY_PATH", llvm_amdgpu_home + "/llvm/lib")
+
+    # Make sure that the compiler paths are in the LD_LIBRARY_PATH
+    def setup_dependent_run_environment(self, env, dependent_spec):
+        llvm_amdgpu_home = self.spec["llvm-amdgpu"].prefix
+        env.prepend_path("LD_LIBRARY_PATH", llvm_amdgpu_home + "/llvm/lib")