diff --git a/var/spack/repos/builtin/packages/py-scipy/package.py b/var/spack/repos/builtin/packages/py-scipy/package.py
index 59b891f1bec..5881ade2108 100644
--- a/var/spack/repos/builtin/packages/py-scipy/package.py
+++ b/var/spack/repos/builtin/packages/py-scipy/package.py
@@ -178,6 +178,10 @@ class PyScipy(PythonPackage):
         msg="SciPy requires at least vc142 (default with Visual Studio 2019) "
         "when building with MSVC",
     )
+
+    # https://github.com/spack/spack/issues/48243
+    conflicts("%intel", when="@1.14:", msg="SciPy 1.14: Use Intel LLVM instead of Intel Classic")
+
     # https://github.com/spack/spack/issues/45718
     conflicts("%aocc", msg="SciPy doesn't compile with AOCC yet")