diff --git a/var/spack/repos/builtin/packages/r-s4vectors/package.py b/var/spack/repos/builtin/packages/r-s4vectors/package.py
index 3a2c2ee7ead..d6b6293f99e 100644
--- a/var/spack/repos/builtin/packages/r-s4vectors/package.py
+++ b/var/spack/repos/builtin/packages/r-s4vectors/package.py
@@ -39,7 +39,9 @@ class RS4vectors(RPackage):
     url      = "https://git.bioconductor.org/packages/S4Vectors"
     list_url = homepage
 
+    version('0.16.0', git='https://git.bioconductor.org/packages/S4Vectors', commit='00fec03fcbcb7cff37917fab0da28d91fdf9dc3d')
     version('0.14.7', git='https://git.bioconductor.org/packages/S4Vectors', commit='40af17fe0b8e93b6a72fc787540d2961773b8e23')
 
-    depends_on('r-biocgenerics', type=('build', 'run'))
-    depends_on('r@3.4.0:3.4.9', when='@0.14.7')
+    depends_on('r-biocgenerics@0.21.1:', type=('build', 'run'), when='@0.14.7')
+    depends_on('r-biocgenerics@0.23.3:', type=('build', 'run'), when='@0.16.0')
+    depends_on('r@3.4.0:3.4.9', when='@0.14.7:')