diff --git a/var/spack/repos/builtin/packages/gobject-introspection/package.py b/var/spack/repos/builtin/packages/gobject-introspection/package.py
index 9ac9aa32e65..3e6e32de13a 100644
--- a/var/spack/repos/builtin/packages/gobject-introspection/package.py
+++ b/var/spack/repos/builtin/packages/gobject-introspection/package.py
@@ -106,6 +106,7 @@ def setup_build_environment(self, env):
         # Only needed for sbang.patch above
         if self.spec.satisfies("@:1.60"):
             env.set("SPACK_SBANG", sbang.sbang_install_path())
+        env.set("GI_SCANNER_DISABLE_CACHE", "1")
 
     def setup_run_environment(self, env):
         env.prepend_path("GI_TYPELIB_PATH", join_path(self.prefix.lib, "girepository-1.0"))
@@ -113,6 +114,7 @@ def setup_run_environment(self, env):
     def setup_dependent_build_environment(self, env, dependent_spec):
         env.prepend_path("XDG_DATA_DIRS", self.prefix.share)
         env.prepend_path("GI_TYPELIB_PATH", join_path(self.prefix.lib, "girepository-1.0"))
+        env.set("GI_SCANNER_DISABLE_CACHE", "1")
 
     def setup_dependent_run_environment(self, env, dependent_spec):
         env.prepend_path("XDG_DATA_DIRS", self.prefix.share)