diff --git a/share/spack/setup-env.fish b/share/spack/setup-env.fish
index e00d8e76bb4..901ffe129f7 100755
--- a/share/spack/setup-env.fish
+++ b/share/spack/setup-env.fish
@@ -372,7 +372,14 @@ end
 
 
 function spack_runner -d "Runner function for the `spack` wrapper"
-
+    # Store DYLD_* variables from spack shell function
+    # This is necessary because MacOS System Integrity Protection clears
+    # variables that affect dyld on process start.
+    for var in DYLD_LIBRARY_PATH DYLD_FALLBACK_LIBRARY_PATH
+        if set -q $var
+            set -gx SPACK_$var $$var
+        end
+    end
 
     #
     # Accumulate initial flags for main spack command