diff --git a/var/spack/repos/builtin/packages/r-dexseq/package.py b/var/spack/repos/builtin/packages/r-dexseq/package.py
index b76c64f5879..9c4f71b439c 100644
--- a/var/spack/repos/builtin/packages/r-dexseq/package.py
+++ b/var/spack/repos/builtin/packages/r-dexseq/package.py
@@ -21,6 +21,7 @@ class RDexseq(RPackage):
 
     maintainers("dorton21")
 
+    version("1.46.0", commit="074c0bf6776eea69e58a788a0f6904dd632a1b74")
     version("1.44.0", commit="9660d7372d5ced1a7e324ed9a61b935023b7d135")
     version("1.42.0", commit="d91de62a27d0cab2ef12ef1a5f23dc2f7a0cfadd")
     version("1.40.0", commit="7d2d639b3a157e443058fc557132cd2629bb36f3")
@@ -32,6 +33,7 @@ class RDexseq(RPackage):
     depends_on("r-iranges@2.5.17:", type=("build", "run"))
     depends_on("r-genomicranges@1.23.7:", type=("build", "run"))
     depends_on("r-deseq2@1.9.11:", type=("build", "run"))
+    depends_on("r-deseq2@1.39.6:", type=("build", "run"), when="@1.46.0:")
     depends_on("r-annotationdbi", type=("build", "run"))
     depends_on("r-rcolorbrewer", type=("build", "run"))
     depends_on("r-s4vectors@0.23.18:", type=("build", "run"))